陈国强

职称：教授

研究方向：合成生物学、微生物代谢工程、生物材料、工业生物技术

通讯地址：chengq@tsinghua.edu.cn

陈国强，长期从事“生物合成PHA材料及其下一代工业生物技术”的研究。在国际学术期刊如Chemical Reviews、Chemical Society Reviews、Science、Advanced Materials, Advanced Science, Nucleic Acids Research、Nature Communications、Trends in Biotechnology、Biomaterials、Metabolic Engineering和Current Opinions in Biotechnology等上共发表微生物技术和生物材料相关论文370多篇， Web of Sciences纪录论文被引用一万九千五百多次(H指数为67) [Google Scholar引用六万多次，H指数大于100]。获得授权专利40项，50个公开专利。开发的技术已经在数家公司用于大规模生产微生物塑料聚羟基脂肪酸酯PHA，使我国成为PHA领域国际上学术和产业最发达的国家、以及其医学应用研究做多的国家。

教育和工作经历

1981-1985 广州华南理工大学，学士

1986-1989 奥地利格拉茨工业大学，博士

1990-1992 英国诺丁汉大学，博士后

1992-1994 加拿大阿尔伯达大学，博士后

1994-1997 清华大学生命科学学院，副教授

1997-至今  清华大学生命科学学院，教授、博导

科技奖励

2016年 全国先进科技工作者

2015年 候德傍化工创新奖

2013年 首届闵恩泽能源化工杰出贡献奖

2011年 谈家祯生命科学创新奖

2004年 教育部高校青年教师奖

2003年 第八届中国青年科技奖

2003年 纽伦堡国际发明奖

2003年 茅以升科技奖

2002年 自然科学基金委国家杰出青年

2002年 国家发明二等奖(排名第一)

连续9年获得清华大学高论文他引的“梅贻琦奖”

连续六年获得Elsevier出版社生化与分子生物学高引用作者

代表性论文

1. Chen GQ and Jiang XR. Engineering Microorganisms for Improving Polyhydroxyalkanoate Biosynthesis. Current Opinion in Biotechnology 53 (2018) 20-25

2. Ouyang PF, Wang H, Hajnal I, Wu W. Guo YY and Chen GQ. Increasing Oxygen Availability for Improving PHB Production by Halomonas. Metabolic Engineering 45 (2018) 20-31

3. Zhang XC, Guo YY, Liu X, Chen XG, Wu Q, Chen GQ. Engineering Cell Wall Synthesis Mechanism for Enhanced PHB Accumulation in E. coli. Metabolic Engineering 45 (2018) 32-42

4. Chen GQ and Jiang XR. Next Generation Industry Biotechnology Based on Exremophiles. Current Opinion in Biotechnology 50 (2018) 94-100

5. Ye JW, Hu DK, Che XM, Jiang XR, Li T, Chen JC, Zhang HQ, Chen GQ. Engineering of Halomonas bluephagenesis for Low Cost Production of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from Glucose. Metabolic Engineering 47 (2018) 143-152

6. Qin Q, Ling C, Zhao YQ, Yang T, Yin J, Guo YY and Chen GQ. CRISPR/Cas9 Editing Genome of Extremophile Halomonas spp. Metabolic Engineering 47 (2018) 219-229

7. Wei DX, Dao JW, Chen GQ. Micro-Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration. Advanced Materials 30 (2018) 1802273 DOI: 10.1002/adma.201802273

8. Ling C, Qiao GQ, Shuai BW, Olavarria K, Yin J, Xiang RJ, Shen YH, Song KN, Guo YY, Chen GQ. Engineering NADH/NAD⁺ Ratio in Halomonas bluephagenesis for Enhanced Production of Polyhydroxyalkanoates (PHA). Metabolic Engineering 49 (2018) 275-286.

9. Li MY, Chen XB, Che XM, Zhang HQ, Wu LP, Du HT and Chen GQ. Engineering Pseudomonas entomophila for Synthesis of Copolymers of 3-Hydroxybutyrate and Medium-chain-length 3-Hydroxyalkanoates. Metabolic Engineering 52 (2018) 253-262

10. Ling C, Qiao GQ, Shuai BW, Song KN, Jiang XR, Chen GQ. Engineering Self-flocculating Halomonas campaniensis for Wastewaterless Open and Continuous Fermentation. Biotechnology and Bioengineering 116 (2019) 805-815

11. Chen Y, Chen XY, Du HT, Zhang X, Ma YM, Chen JC, Ye JW, Jiang XR, Chen GQ. Chromosome Engineering the TCA Cycle in Halomonas bluephagenesis for Production of Copolymers of 3-Hydroxybutyrate and 3-Hydroxyvalerate (PHBV). Metabolic Engineering 54 (2019) 69-82

12. Shen R, Ning ZY, Lan YX, Chen JC and Chen GQ. Manipulation of Polyhydroxyalkanoate Granular sizes in Halomonas bluephagenesis. Metabolic Engineering 54 (2019) 117-126.

13. Wang Y, Ling C, Chen Y, Jiang XR and Chen GQ, Microbial Engineering for Easy Downstream Processing. Biotechnology Advances 37 (2019) 107365. 10.1016/j.biotechadv.2019.03.004

14. Ye JW, Hu DK, Yin J, Huang WZ, Xiang RJ, Zhang LZ, Wang X, Han JN, Chen GQ. Stimulus Response-based Fine-Tuning of Polyhydroxyalkanoate Pathway in Halomonas. Metabolic Engineering 57 (2019) 85-95

15. Zheng Y, Meng FK, Wei WJ; Sun Z; Lou CB and Chen GQ. A Tight Cold-inducible Switch Built by Coupling Thermosensitive Transcriptional and Proteolytic Regulatory Parts. Nucleic Acids Research 47 (21) e137 (2019) doi: 10.1093/nar/gkz785 (2019)

16. Zheng Y, Chen JC, Ma YM, Chen GQ. Engineering Biosynthesis of Polyhydroxyalkanoates (PHA) for Diversity and Cost Reduction. Metabolic Engineering 58 (2020) 82-93

17. Yu LP, Yan X, Zhang X, Chen XB, Wu Q, Jiang XR, Chen GQ. Biosynthesis of Functional Polyhydroxyalkanoates by Engineered Halomonas bluephagenesis Metabolic Engineering 59 (2020) 119-130.